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Invitrogen
PYDC1 Polyclonal Antibody
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PYDC1 Antibody (PA5-102846) in IHC (P)
Immunohistochemistry analysis of PYDC1 in rat brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PYDC1 polyclonal antibody (Product # PA5-102846) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102846
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PYDC1(Accession Q8WXC3), corresponding to amino acid residues M1-P31.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ASC2.
靶标信息
ASC2 associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cellular POP1; PAAD containing protein; PAAD-only protein 1; PYC1; PYD (pyrin domain) containing 1; pyrin family member; pyrin-only protein 1; unnamed protein product
基因别名: ASC2; cPOP1; POP1; PYC1
UniProt ID: (Human) Q8WXC3
Entrez Gene ID: (Human) 260434
immune system process
defense response
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of interleukin-1 beta production
positive regulation of interleukin-1 beta production
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
response to other organism
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of interleukin-1-mediated signaling pathway
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