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Invitrogen
PYROXD1 Polyclonal Antibody
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产品信息
PA5-58341
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MCEVKKIYLQ DEFRILKKKS FTFPRDHKSV TADTEMWPVY VELTNEKIYG CDFIVSATGV TPNVEPFLHG NSFDLGEDGG LKVDDHMHTS LPDIYAAG
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 81%.
靶标信息
The PYROXD1 gene encodes the protein pyridine nucleotide-disulphide oxidoreductase domain 1, which has a significant role in mitochondrial function and cellular redox homeostasis. This gene is involved in maintaining the balance of oxidative stress within cells and is crucial for the redox regulation of cellular components, impacting processes like energy metabolism and apoptosis. Mutations in PYROXD1 have been associated with early-onset myopathy, indicating its importance in muscle development and maintenance. The protein encoded by PYROXD1 is part of the oxidoreductase enzyme family that facilitates electron transfer, contributing to cellular defense against oxidative damage. Recent studies have linked PYROXD1 to various neuromuscular disorders, where disruptions in its function affect muscle fiber alignment and force production. Understanding its role in redox biology is crucial for developing therapeutic strategies to combat muscle pathologies and redox-related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ22028; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
基因别名: PYROXD1
UniProt ID: (Human) Q8WU10
Entrez Gene ID: (Human) 79912
