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Pan RhO Polyclonal Antibody

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Pan RhO Polyclonal Antibody

产品信息

OSC00095G-500UG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

10-50 µg/mL
-

免疫组化 (IHC)

10-50 µg/mL
-

其他PubMed (Misc)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from aa region 50-100 of RhOA, RhOB, RhOC, RhOF, RhOQ and RAC1, RAC2, RAC3 and CDC42 conjugated to blue carrier protein was used as the antigen
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

规格

500 µg

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: RhO family.

靶标信息

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: aplysia ras-related homolog 9 (RhoC); aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; aplysia ras-related homolog B; h12; h6; h9; induced in fatty liver dystrophy 1; plysia ras-related homolog A2; Ras family member A; ras homolog 9 (RhoC); ras homolog A1; ras homolog A2; ras homolog B; ras homolog family member F (in filopodia); ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member AB; ras homolog gene family, member B; ras homolog gene family, member C; ras homolog gene family, member f (in filopodia); ras homolog gene family, member Q; Ras-like protein family member 7A; Ras-like protein TC10; ras-related GTP-binding protein TC10; Rho cDNA clone 12; Rho cDNA clone 6; Rho cDNA clone 9; rho family; Rho family GTPase; Rho family GTPase Rif; Rho in filopodia; Rho-related GTP-binding protein RhoB; Rho-related GTP-binding protein RhoC; Rho-related GTP-binding protein RhoF; Rho-related GTP-binding protein RhoQ; rhoB; SIG-61; Silica-induced gene 61 protein; small GTPase Tc10; Transforming protein RhoA

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基因别名: AA017882; AI324259; AI845056; ARH12; ARH6; ARH9; ARHA; Arha1; Arha2; ARHB; ARHC; ARHF; ARHQ; AV026554; Ifld1; RASL7A; RHO12; RHOA; RHOB; RHOC; RHOF; RHOQ; RIF; TC10; TC10A

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UniProt ID: (Rat) P61589, (Mouse) Q9QUI0, (Rat) P62747, (Mouse) P62746, (Mouse) Q62159, (Mouse) Q8BYP3, (Mouse) Q8R527, (Rat) Q9JJL4

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Entrez Gene ID: (Rat) 117273, (Mouse) 11848, (Rat) 64373, (Mouse) 11852, (Mouse) 11853, (Rat) 295342, (Rat) 690130, (Mouse) 23912, (Mouse) 104215, (Rat) 85428

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功能
GTPase activity protein binding GTP binding myosin binding GDP binding protein domain specific binding Rho GDP-dissociation inhibitor binding nucleotide binding signal transducer activity profilin binding GBD domain binding small GTPase
参与通路
cell morphogenesis response to hypoxia regulation of transcription from RNA polymerase II promoter cytoskeleton organization cell adhesion cell-matrix adhesion small GTPase mediated signal transduction skeletal muscle tissue development regulation of actin polymerization or depolymerization metabolic process response to mechanical stimulus response to glucose regulation of neuron projection development substantia nigra development cerebral cortex cell migration forebrain radial glial cell differentiation actin cytoskeleton organization cell differentiation positive regulation of cell growth regulation of cell migration positive regulation of cell migration androgen receptor signaling pathway positive regulation of actin filament polymerization stress-activated protein kinase signaling cascade positive regulation of cytokinesis negative regulation of intracellular steroid hormone receptor signaling pathway regulation of osteoblast proliferation cleavage furrow formation apolipoprotein A-I-mediated signaling pathway response to drug positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling stress fiber assembly response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process apical junction assembly negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process ossification involved in bone maturation wound healing, spreading of cells response to ethanol negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of translation positive regulation of cell adhesion positive regulation of vasoconstriction positive regulation of smooth muscle contraction neuron projection morphogenesis regulation of dendrite development negative chemotaxis response to glucocorticoid positive regulation of stress fiber assembly regulation of calcium ion transport negative regulation of cell death trabecula morphogenesis cellular response to progesterone stimulus positive regulation of podosome assembly mitotic spindle assembly skeletal muscle satellite cell migration regulation of neural precursor cell proliferation cell cycle integrin-mediated signaling pathway Rho protein signal transduction GTP metabolic process cell division positive regulation of lipase activity angiogenesis intracellular protein transport obsolete transformed cell apoptotic process endosome to lysosome transport positive regulation of apoptotic process positive regulation of angiogenesis negative regulation of cell cycle cellular response to hydrogen peroxide cellular response to ionizing radiation cytokinesis transport apoptotic process multicellular organism development protein transport signal transduction actin filament organization insulin receptor signaling pathway regulation of cell shape cortical actin cytoskeleton organization cellular response to insulin stimulus positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import positive regulation of glucose import positive regulation of filopodium assembly negative regulation of establishment of protein localization to plasma membrane
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