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Invitrogen
Pan-cadherin Polyclonal Antibody
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Pan-cadherin Antibody (PA5-16766) in ICC/IF
Immunofluorescence analysis of Cadherin Pan was done on 70% confluent log phase PC-3 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Cadherin Pan Rabbit Polyclonal Antibody (Product # PA5-16766) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room... View More
产品信息
PA5-16766
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the C-terminus of chicken N-cadherin
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
4°C
运输条件
Wet ice
RRID
产品详细信息
PA5-16766 targets Cadherin Pan in IHC (P) and WB applications and shows reactivity with Bovine, Canine, Chicken, Human, mouse, Non-human primate, Rat, and Xenopus laevis samples. This antibody recognizes Cadherin E, N, P and R (Cadherin 1, 2, 3 and 4).
The PA5-16766 immunogen is a synthetic peptide from the C-terminus of chicken N-cadherin.
靶标信息
Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
