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Invitrogen
Pdx1 Monoclonal Antibody (2A12), eBioscience™
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Pdx1 Antibody (14-6500-82) in IHC (P)
Immunohistochemistry of formalin-fixed paraffin embedded human pancreas using 5 µg/mL of Mouse IgG1 Isotype Control Purified (Product # 14-4714-82) (left) or 5 µg/mL Anti-Human PDX1 Purified (right) followed by Anti-Mouse IgG HRP, and DAB visualization.Nuclei are counterstained with hematoxylin.
产品信息
14-6500-82
产品规格
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2A12
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
4°C
运输条件
Wet ice
RRID
产品详细信息
Description: This 2A12 monoclonal antibody reacts with the transcriptional activator PDX1, also known as pancreatic and duodenal homeobox protein and insulin promoter factor. Early expression of PDX1 during development marks the endoderm from which the pancreas, stomach, and duodenum derive. In the mature pancreas, expression is found in insulin-expressing beta-cells. PDX1 functions as an important regulator of several key pancreatic proteins including insulin, somatostatin, glucokinase, islet amyloid factor, and glucose transporter type 2. Deficiency in PDX1 results in a dysregulation of the beta-cell compensation of insulin resistance, which can lead to late-onset type 2 diabetes mellitus (formerly NIDDM) and maturity onset diabetes of the young type 4 (MODY4).
Applications Reported: This 2A12 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.
Applications Tested: This 2A12 antibody has been tested by immunohistochemistry on FFPE human pancreas (with IHC Antigen Retrieval Solution - Low pH (cat. 00-4955)) and can be used at less than or equal to 5 µg/mL. Is is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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