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Rockland
Penicillinase Polyclonal Antibody, HRP
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产品信息
200-4375-0100
产品规格
种属反应
Fungi
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Penicillinase [Enterobacter cloacae]
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Ion-exchange chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl, 10mg/mL BSA
内含物
0.01% gentamicin sulfate
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Penicillinase is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Peroxidase, anti-Rabbit Serum as well as purified and partially purified Penicillinase [Enterobacter cloacae]. Cross reactivity against Penicillinase from other tissues and species may occur but have not been specifically determined.
靶标信息
Penicillinase, also known as beta-lactamase, is an enzyme produced by certain bacteria that confers resistance to penicillin and other beta-lactam antibiotics. This enzyme works by hydrolyzing the beta-lactam ring of penicillin, rendering the antibiotic ineffective in inhibiting bacterial cell wall synthesis. Penicillinase is encoded by various bacterial genes, commonly found in plasmids or chromosomes, which can be transferred between bacteria, leading to the spread of antibiotic resistance. This enzyme is a significant concern in treating bacterial infections, as it diminishes the efficacy of beta-lactam antibiotics, which are widely used in clinical settings. The presence of penicillinase-producing bacteria necessitates the use of alternative antibiotics or combination therapies that include beta-lactamase inhibitors, such as clavulanic acid, to restore the antibiotic's effectiveness. Monitoring and studying penicillinase activity are crucial for managing antibiotic resistance and developing new therapeutic strategies to combat resistant bacterial strains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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