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Proteintech
Perforin Polyclonal Antibody
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产品信息
14580-1-AP
产品规格
种属反应
Human,
Mouse
已发表种属
Chicken
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Perforin Fusion Protein Ag6060 (247-555 aa encoded by BC063043)
偶联物
形式
Liquid
浓度
0.28 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EGLTDNEVE DCLTVEAQVN IGIHGSISAE AKACEEKKKK HKMTASFHQT YRERHSEVVG GHHTSINDLL FGIQAGPEQY SAWVNSLPGS PGLVDYTLEP LHVLLDSQDP RREALRRALS QYLTDRARWR DCSRPCPPGR QKSPRDPCQC VCHGSAVTTQ DCCPRQRGLA QLEVTFIQAW GLWGDWFTAT DAYVKLFFGG QELRTSTVWD NNNPIWSVRL DFGDVLLATG GPLRLQVWDQ DSGRDDDLLG TCDQAPKSGS HEVRCNLNHG HLKFRYHARC LPHLGGGTCL DYVPQMLLGE PPGNRSGAVW (247-555 aa encoded by BC063043)
靶标信息
Perforin is one of the major cytolytic proteins of cytolytic granules. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Moreover, perforin is involved in immune defense against tumors and virus infections as mediated by cytotoxic lymphocytes. Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, and has a molecular weight of 70 to 75 kD. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9, and homology between perforin and C9 have been demonstrated. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested. Perforin is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cytolysin; lymphocyte pore forming protein; Lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1 (pore forming protein); Perforin-1; Perforin1; PFP; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; PRF1 (pore forming protein 1); RP11-710A11.3
基因别名: FLH2; HPLH2; P1; Pfn; PFN1; PFP; Prf-1; PRF1
UniProt ID: (Human) P14222, (Mouse) P10820
Entrez Gene ID: (Human) 5551, (Mouse) 18646
