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Invitrogen
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Positive test controls include: Jurkat, NIH/3T3, C6. The target is usually found in the following locations: Cell membrane, Cytoplasm, Nucleus.
Immunogen sequence: MKTFC
AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AKT1 kinase; Akt1m protein; C-AKT; CAKT; PKB; PKB alpha; PKB beta; PKB gamma; PKBG; Protein kinase B; Protein kinase B alpha; protein kinase B-alpha; Proto-oncogene c-Akt; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-beta; RAC-PK-gamma; related to A and C kinases; Thymoma viral proto-oncogene
基因别名: Akt; Akt1; PKB; PKB/Akt; PKBalpha; Rac
UniProt ID: (Mouse) P31750
Entrez Gene ID: (Mouse) 11651