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Invitrogen
Phospho-AMPK alpha-1,2 (Thr172, Thr183) Polyclonal Antibody
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Phospho-AMPK alpha-1,2 (Thr172, Thr183) Antibody (PA5-36764) in IHC (P)
Immunohistochemical analysis of Phospho-AMPK alpha-1 pThr172+AMPK alpha-2 pThr183 in paraffin-embedded human breast carcinoma using Phospho-AMPK alpha-1 pThr172+AMPK alpha-2 pThr183 polyclonal antibody (Product # PA5-36764) at a dilution of 1:100.
产品信息
PA5-36764
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide derived from human AMPK alpha1 around the phosphorylation site of Threonine 183
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody detects endogenous protein at a molecular weight of 63 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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