Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:1,000 | 查看10篇已发表文章 10篇已发表文章 |
产品规格 | |
---|---|
种属反应 |
Bovine, Chicken, Human, Mouse, Non-human primate, Pig, Rat |
已发表种属 |
Human, Mouse, Pig, Plant, Sheep |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic phosphopeptides corresponding to residues surrounding Thr183 of human AMPKa 1 and Thr172 of AMPKa 2 |
偶联物 |
Unconjugated |
形式 |
Liquid |
纯化类型 |
Antigen affinity chromatography |
保存液 |
0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100µg/mL BSA |
内含物 |
no preservative |
保存条件 |
-20°C |
RRID |
AB_10983715 |
It is not recommended to aliquot this antibody.
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5'-AMP-activated protein kinase alpha-1 catalytic subunit; 5'-AMP-activated protein kinase alpha-2 catalytic subunit; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; 63 kDa subunit; AAPK2; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase; AMP-activated protein kinase alpha 2; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMP-activated protein kinase, alpha 1 catalytic subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK 63 kDa subunit; AMPK alpha 1; AMPK alpha 2; AMPK alpha-1 chain; AMPK alpha-2 chain; AMPK subunit alpha-1; AMPK subunit alpha-2; AMPK-activated protein kinase alpha-2 subunit; AMPK-alpha-1 chain; AMPK-alpha-2 chain; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; pAMPK; prkaa2; protein kinase; protein kinase AMP-activated alpha 2 catalytic subunit; protein kinase, AMP-activated, alpha 1 catalytic subunit; protein kinase, AMP-activated, alpha 2 catalytic subunit; Tau-protein kinase PRKAA1
基因别名: 2310008I11Rik; A830082D05; AI194361; AI450832; AL024255; AMPK; AMPK1; AMPK2; AMPKa1; AMPKA2; AMPKalpha1; AMPKalpha2; C130083N04Rik; PRKAA; PRKAA1; PRKAA2
UniProt ID: (Human) Q13131, (Human) P54646, (Pig) Q28948, (Rat) P54645, (Mouse) Q5EG47, (Rat) Q09137, (Mouse) Q8BRK8
Entrez Gene ID: (Pig) 100145903, (Chicken) 427185, (Human) 5562, (Bovine) 540404, (Bovine) 538954, (Human) 5563, (Pig) 397504, (Chicken) 429110, (Rat) 65248, (Mouse) 105787, (Rat) 78975, (Mouse) 108079