Invitrogen

Phospho-AP2M1 (Thr156) Polyclonal Antibody

产品信息

PA5-64813

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-

产品规格
种属反应	Human, Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human AP-2mu (Phospho-Thr156) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2664364

产品详细信息

Phospho-AP2M1 (Thr156) Polyclonal Antibody detects endogenous levels of AP2M1 only when phosphorylated at Thr156.

靶标信息

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: adapter-related protein complex 2 mu subunit; adapter-related protein complex 2 subunit mu; Adaptin-mu2; Adaptor protein complex AP-2 subunit mu; adaptor related protein complex 2, mu 1 subunit; Adaptor-related protein complex 2 subunit mu; adaptor-related protein complex 2, mu 1 subunit; AP-2 complex subunit mu; AP-2 mu 2 chain; AP-2 mu chain; clathrin adaptor complex AP2, mu subunit; clathrin assembly protein complex 2 medium chain; Clathrin assembly protein complex 2 mu medium chain; clathrin coat adaptor protein AP50; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; clathrin-associated/assembly/adaptor protein, medium 1; coat assembly protein complex 50 kD; HA2 50 kDA subunit; Mu2-adaptin; Plasma membrane adaptor AP-2 50 kDa protein; plasma membrane adaptor AP-2 50kDA protein

基因别名: AP2M1; AP50; CLAPM1; KIAA0109; mu2

UniProt ID: (Human) Q96CW1, (Rat) P84092, (Mouse) P84091

Entrez Gene ID: (Human) 1173, (Rat) 116563, (Mouse) 11773

分子生物学功能: membrane traffic protein