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Antibody detects endogenous levels of ARHGAP42 only when phosphorylated at Tyr792.
This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: arhgap42; Rho GTPase activating protein 42; Rho GTPase-activating protein 10-like; Rho GTPase-activating protein 42; Rho-type GTPase-activating protein 42; VRho GTPase activating protein 42
基因别名: 9030420J04Rik; ARHGAP42; BE136619; GRAF3; RGD1564081; TMEM133
UniProt ID: (Human) A6NI28, (Mouse) B2RQE8
Entrez Gene ID: (Human) 143872, (Mouse) 71544, (Rat) 500943