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产品信息
PA5-64498
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:1,000-1:3,000 | - |
免疫组化 (IHC) |
1:50-1:200 | - |
酶联免疫吸附实验 (ELISA) |
1:20,000-1:40,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human B-Myb (Phospho-Thr494/497) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2662895 |
产品详细信息
Phospho-B-Myb (Thr494, 497) Polyclonal Antibody detects endogenous levels of B-Myb only when phosphorylated at Thr494, 497.
靶标信息
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B Myb; B-Myb; HGNC:7548; MGC15600; Myb-like protein 2; Myb-related protein B; v-myb avian myeloblastosis viral oncogene homolog-like 2; v-myb myeloblastosis viral oncogene homolog-like 2
基因别名: B-MYB; BMYB; MYBL2
UniProt ID: (Human) P10244, (Mouse) P48972
Entrez Gene ID: (Human) 4605, (Rat) 296344, (Mouse) 17865
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II transcription factor recruiting
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin binding
DNA binding
