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Invitrogen
Phospho-BRCA1 (Ser1497) Polyclonal Antibody
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Phospho-BRCA1 (Ser1497) Antibody (PA5-64621) in ICC/IF
Frontiers in cell and developmental biology 2025 -
FIGURE 7 Oxaliplatin inhibits HR repair pathways via blocking both CDK1-BRCA1. (A) Representative images of immunofluorescent CDK1 phosphorylation and BRCA1 phosphorylation staining of Olaparib + exaliplatin, Oxaliplatin, Olaparib, and blank control group in MKN74, SNU719, AGS Oxaliplatin resistance cell lines. The scale represents 20 um. Drug action time was 36 h. (B,C) Proportion of CDK1 phosphorylation a... View More
产品信息
PA5-64621
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BRCA1 (Phospho-Ser1497)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Phospho-BRCA1 (Ser1497) Polyclonal Antibody detects endogenous levels of BRCA1 only when phosphorylated at Ser1497.
靶标信息
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
