Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human Bim (Phospho-Ser44/104) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2662118 |
Phospho-Bim (Ser44, 104) Polyclonal Antibody detects endogenous levels of Bim only when phosphorylated at Ser44, 104.
BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl-2 like 11; Bcl-2 related apoptotic gene product BimL; Bcl-2-like protein 11; bcl-2-related ovarian death agonist; Bcl-2-related ovarian death protein; Bcl2 interacting mediator of cell death; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bim EL; Bim-A; BIM-alpha6; BIM-beta6; BIM-beta7; OTTHUMP00000197013; OTTHUMP00000204247
基因别名: 1500006F24Rik; BAM; bcl2-L-11; BCL2L11; BIM; BimL; BOD
UniProt ID: (Human) Q8WYL9, (Mouse) O54918, (Rat) O88498
Entrez Gene ID: (Human) 10018, (Mouse) 12125, (Rat) 64547