Invitrogen

Phospho-CDK6 (Tyr24) Polyclonal Antibody

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Phospho-CDK6 (Tyr24) Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence staining of methanol-fixed Hela cells using CDK6 (pTyr24) polyclonal antibody (Product # PA5-37518).

Phospho-CDK6 (Tyr24) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded human colon carcinoma using CDK6 (pTyr24) polyclonal antibody (Product # PA5-37518) (left) or the same antibody preincubated with a blocking peptide (right).

Phospho-CDK6 (Tyr24) Antibody in Western Blot (WB) — Western blot analysis of extracts from 293 cells, untreated (Lane 1) or treated with starvation (Lane 2), using CDK6 (pTyr24) polyclonal antibody (Product # PA5-37518).

产品信息

PA5-37518

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:1,000	-
免疫组化（石蜡） (IHC (P))	1:50-1:100	-
免疫细胞化学 (ICC/IF)	1:100-1:200	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Peptide sequence around phosphorylation site of tyrosine 24 (G-A-Y(p)-G-K) derived from Human CDK6.
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2554127

产品详细信息

A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human colon carcinoma; suggested positive control for ICC/IF is Hela cells.

靶标信息

Cyclin-dependent kinase 6 (p40cdk6 also known as PLSTIRE) belongs to a family of proteins designated as cdks. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene results in microcephaly 12, primary, autosomal recessive (MCPH12).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Cell division protein kinase 6; CR2 protein kinase; CRK2; Cyclin-dependent kinase 6; MGC59692; Serine/threonine-protein kinase PLSTIRE

基因别名: 5830411I20; AI504062; CDK6; CDKN6; Crk2; MCPH12; PLSTIRE

UniProt ID: (Human) Q00534, (Mouse) Q64261

Entrez Gene ID: (Human) 1021, (Mouse) 12571

分子生物学功能: non-receptor serine/threonine protein kinase

G1/S transition of mitotic cell cycle positive regulation of cell-matrix adhesion type B pancreatic cell development protein phosphorylation cell cycle arrest Notch signaling pathway negative regulation of cell proliferation response to virus regulation of gene expression positive regulation of gene expression astrocyte development dentate gyrus development lateral ventricle development T cell differentiation in thymus gliogenesis cell dedifferentiation negative regulation of cell differentiation negative regulation of myeloid cell differentiation regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of osteoblast differentiation negative regulation of cell cycle positive regulation of fibroblast proliferation generation of neurons negative regulation of epithelial cell proliferation cell division hematopoietic stem cell differentiation cellular response to phorbol 13-acetate 12-myristate regulation of cell motility negative regulation of cellular senescence hematopoietic progenitor cell differentiation cell cycle phosphorylation hemopoiesis cell differentiation regulation of cell proliferation

参与通路

cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding cyclin binding nucleotide binding protein kinase activity protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups