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Antibody detects endogenous levels of CENPA only when phosphorylated at Ser7.
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CENP A; CENP-A; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; centromere-specific histone; Histone H3-like centromeric protein A
基因别名: CenH3; CENP-A; CENPA; RGD1563607
UniProt ID: (Human) P49450, (Mouse) O35216
Entrez Gene ID: (Human) 1058, (Mouse) 12615, (Rat) 298850