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Invitrogen
Phospho-COT/TPL-2 (Thr290) Polyclonal Antibody
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产品信息
PA5-35657
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from human COT around the phosphorylation site of Threonine 290
偶联物
形式
Liquid
浓度
Lot-Specific
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
靶标信息
COT (MAP3K8) is required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages. It is critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. COT is involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. It is also involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, COT activates the MAPK/ERK pathway in response to IL1 in an IRAK-1-independent manner and leads to the up-regulation of IL8 and CCL4. COT also transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages and may play a role in the regulation of immunoglobulin production. In adipocytes, COT activates MAPK/ERK pathway in an IKBKB-dependent manner in respone to IL1B and TNF (but not insulin).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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