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Phospho-CaMKII (Thr305,Thr306) Antibody (711389) in ICC/IF
For immunofluorescence analysis SH-SY5Y cells were fixed and permeabilized for detection of endogenous CamKIIpT305/306 using Anti-CamKIIpT305/306 Recombinant Rabbit Polyclonal Antibody (Product # 711389, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for... View More
产品信息
711389
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
抗原
Peptide corresponding to Human CAMK2G (aa 300-309)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2632970
产品详细信息
This antibody is predicted to react with Monkey, Horse and Bat
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates a number of cellular functions including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostatsis. Autophosphorylation of threonine 286 in the presence of Ca2+ and calmodulin activates CAMK2A with the ability to switch from calmodulin-dependent to a calmodulin independent activity. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calci; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaM-kinase II alpha chain; CaMK-II alpha subunit; caMK-II subunit alpha; CaMKIINalpha; EC 2.7.11.17; OTTHUMP00000165787; OTTHUMP00000165788; Phospho-CaMKI
基因别名: CAMK2A; CAMKA; KIAA0968
UniProt ID: (Human) Q9UQM7
Entrez Gene ID: (Human) 815
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
calmodulin binding
ATP binding
kinase activity
glutamate receptor binding
protein homodimerization activity
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
MAPK cascade
response to ischemia
protein phosphorylation
calcium ion transport
Wnt signaling pathway, calcium modulating pathway
positive regulation of cardiac muscle cell apoptotic process
peptidyl-serine phosphorylation
angiotensin-activated signaling pathway
positive regulation of GTPase activity
protein autophosphorylation
regulation of neurotransmitter secretion
regulation of neuronal synaptic plasticity
positive regulation of NF-kappaB transcription factor activity
positive regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of cellular response to heat
regulation of mitochondrial membrane permeability involved in apoptotic process
