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产品信息
PA5-64547
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human Caveolin 2 (Phospho-Ser36) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2662933 |
产品详细信息
Phospho-Caveolin 2 (Ser36) Polyclonal Antibody detects endogenous levels of Caveolin 2 only when phosphorylated at Ser36.
靶标信息
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caveolae; caveolae protein, 20-kD; caveolin 2 isoform a and b; Caveolin-2; MGC12294; Phospho-CAV2
基因别名: CAV; CAV2
UniProt ID: (Human) P51636
Entrez Gene ID: (Human) 858
分子生物学功能:
scaffold/adaptor protein
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
vesicle fusion
mitochondrion organization
endoplasmic reticulum organization
regulation of mitotic nuclear division
insulin receptor signaling pathway
vesicle organization
receptor-mediated endocytosis of virus by host cell
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of GTPase activity
positive regulation by host of viral release from host cell
positive regulation by host of viral process
vesicle docking
skeletal muscle fiber development
protein oligomerization
positive regulation of dopamine receptor signaling pathway
caveola assembly
