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Antibody detects endogenous levels of Chk1 only when phosphorylated at Serine 301.
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell cycle checkpoint kinase; checkpoint kinase 1 homolog; Checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27 homolog; Serine/threonine-protein kinase Chk1
基因别名: C85740; CHEK1; CHK1; rad27
UniProt ID: (Human) O14757, (Rat) Q91ZN7, (Mouse) O35280
Entrez Gene ID: (Human) 1111, (Rat) 140583, (Mouse) 12649
分子生物学功能:
glycosyltransferase
non-receptor serine/threonine protein kinase