Invitrogen

Phospho-CtBP1/CtBP2 (Ser158, Ser164) Polyclonal Antibody

查看其他3个CtBP1/CtBP2抗体

产品信息

PA5-64665

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-

产品规格
种属反应	Human
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human CtBP1/2 (Phospho-Ser158/164) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2663240

产品详细信息

Phospho-CtBP1/CtBP2 (Ser158, 164) Polyclonal Antibody detects endogenous levels of CtBP1/CtBP2 only when phosphorylated at Ser158, 164.

靶标信息

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; C-terminal-binding protein 2; CtBP1; CtBP2; ribeye

基因别名: BARS; CTBP; CTBP1; CTBP2

UniProt ID: (Human) Q13363, (Human) P56545

Entrez Gene ID: (Human) 1487, (Human) 1488

分子生物学功能: transcription cofactor

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated protein phosphorylation negative regulation of cell proliferation viral genome replication positive regulation of histone deacetylation negative regulation of histone acetylation negative regulation of transcription, DNA-templated white fat cell differentiation regulation of cell cycle oxidation-reduction process negative regulation of histone H4 acetylation negative regulation of transcription from RNA polymerase II promoter by histone modification positive regulation of chromatin binding positive regulation of transcription from RNA polymerase II promoter positive regulation of retinoic acid receptor signaling pathway

参与通路

RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding protein binding protein C-terminus binding transcription factor binding oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein domain specific binding protein homodimerization activity NAD binding repressing transcription factor binding chromatin binding transcription coactivator activity transcription corepressor activity retinoic acid receptor binding