Invitrogen

Phospho-CtIP (Ser327) Polyclonal Antibody

产品信息

PA5-64481

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:1,000	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human CTIP (Phospho-Ser327) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.3, with 30% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2663877

产品详细信息

Phospho-CtIP (Ser327) Polyclonal Antibody detects endogenous levels of CtIP only when phosphorylated at Ser327.

靶标信息

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CTBP-interacting protein; CtIP; DNA endonuclease RBBP8; RBBP-8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RIM; SAE2; Sporulation in the absence of SPO11 protein 2 homolog

基因别名: 9930104E21Rik; COM1; CTIP; JWDS; RBBP-8; RBBP8; RIM; SAE2; SCKL2

UniProt ID: (Human) Q99708, (Mouse) Q80YR6

Entrez Gene ID: (Human) 5932, (Mouse) 225182

分子生物学功能: transcription cofactor gene-specific transcriptional regulator