Invitrogen

Phospho-DAPK1 (Ser736) Polyclonal Antibody

查看其他21个DAPK1抗体

产品信息

PA5-64572

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:1,000	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human DAPK1 (Phospho-Ser736) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.3, with 30% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2663876

产品详细信息

Phospho-DAPK1 (Ser736) Polyclonal Antibody detects endogenous levels of DAPK1 only when phosphorylated at Ser736.

靶标信息

DAPK1 (death-associated protein kinase 1) is a calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: DAP kinase 1; Death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193

基因别名: D13Ucla1; DAP-Kinase; DAPK; DAPK1

UniProt ID: (Human) P53355, (Mouse) Q80YE7

Entrez Gene ID: (Human) 1612, (Mouse) 69635

分子生物学功能: non-receptor serine/threonine protein kinase

protein phosphorylation apoptotic process extrinsic apoptotic signaling pathway via death domain receptors regulation of autophagy negative regulation of translation intracellular signal transduction regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein autophosphorylation cellular response to interferon-gamma apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of translation signal transduction phosphorylation negative regulation of apoptotic process

参与通路

protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding GTP binding syntaxin-1 binding identical protein binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups