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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
Assay-Dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser554 conjugated to KLH |
偶联物 |
Unconjugated |
形式 |
liquid |
浓度 |
0.25 mg/mL |
纯化类型 |
Antigen Affinity Chromatography |
保存液 |
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol |
内含物 |
no preservative |
保存条件 |
-20°C |
RRID |
AB_2807470 |
Antigen Affinity Purified from Pooled Serum
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12. Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DENN domain-containing protein 3; DENN/MADD domain containing 3
基因别名: DENND3; KIAA0870
UniProt ID: (Human) A2RUS2
Entrez Gene ID: (Human) 22898
