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It is not recommended to aliquot this antibody.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; c-erb B2/neu protein; CD340; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; Epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 1; herstatin; human epidermal growth factor receptor 2; Metastatic lymph node gene 19 protein; MLN 19; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; Oncogene ERBB; p185erbB2; Proto-oncogene c-ErbB-1; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-1; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; wa2; Wa5
基因别名: CD340; EGFR; ERBB; ERBB1; ERBB2; HER-2; HER-2/neu; HER1; HER2; mENA; MLN 19; MLN19; NEU; NGL; NISBD2; PIG61; TKR1
UniProt ID: (Human) P00533, (Human) P04626
Entrez Gene ID: (Human) 1956, (Human) 2064
分子生物学功能:
transmembrane signal receptor