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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthetic phosphopeptide derived from human Ephrin B around the phosphorylation site of Tyr330 (N-I-YP-Y-K) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2554670 |
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CEK5 receptor ligand; CEK5-L; CEL5-L; EFL-3; EFL6; EFNB3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B3; Ephrin-B1; Ephrin-B1 C-terminal fragment; Ephrin-B1 CTF; Ephrin-B1 ICD; Ephrin-B1 intracellular domain; Ephrin-B1 precursor; EphrinB1; EPLG8; kinase ephrin-B1; LERK-2; LERK8; Stimulated by retinoic acid gene 1 protein; STRA1 protein
基因别名: Cek5-L; CFND; CFNS; EFB1; EFL-3; EFL3; EFNB1; Elk-L; Epl2; EPLG2; LERK-2; LERK2; Stra1
UniProt ID: (Human) P98172, (Mouse) P52795
Entrez Gene ID: (Human) 1947, (Rat) 25186, (Mouse) 13641
分子生物学功能:
membrane-bound signaling molecule
