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Invitrogen

Phospho-ErbB2 (HER-2) (Tyr877) Polyclonal Antibody

查看其他71个Her-2 (ErbB2)抗体
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Protocols 实验方案
Tech Support Created with sketchtool. 技术支持

产品信息

PA5-17849

应用 建议稀释比 已发表文章

免疫印迹 (WB)

 1:1,000 -
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

 Rabbit / IgG

分类

 Polyclonal

类型

 Antibody

抗原

Synthetic phosphopeptide corresponding to residues surrounding pTyr877 of human ErbB2

偶联物

 Unconjugated

形式

 Liquid

纯化类型

 Antigen affinity chromatography

保存液

 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

 no preservative

保存条件

 -20°C

RRID

AB_10981759

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

基因别名: c-erbB2; c-neu; CD340; Erbb-2; ERBB2; HER-2; HER-2/neu; HER2; Kiaa3023; mKIAA3023; MLN 19; MLN19; NEU; NGL; TKR1

UniProt ID: (Human) P04626, (Mouse) P70424

Entrez Gene ID: (Human) 2064, (Mouse) 13866, (Rat) 24337

分子生物学功能: transmembrane signal receptor

功能
MAPK cascade positive regulation of protein phosphorylation transcription, DNA-templated protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance cell proliferation phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation positive regulation of cell growth regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus ERBB2 signaling pathway wound healing myelination positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase III promoter protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling oligodendrocyte differentiation positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of protein targeting to membrane regulation of cell motility regulation of transcription, DNA-templated nervous system development positive regulation of cell proliferation glial cell differentiation positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation negative regulation of apoptotic process positive regulation of MAPK cascade estrous cycle positive regulation of Ras protein signal transduction sympathetic nervous system development response to axon injury liver development central nervous system development skeletal muscle tissue development signal transduction by protein phosphorylation response to progesterone regulation of cell proliferation response to drug tongue development regulation of cell differentiation mammary gland involution
参与通路
RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding growth factor binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity nucleotide binding glycoprotein binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ubiquitin protein ligase binding Hsp90 protein binding DNA binding

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