Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:1,000 | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthesized peptide derived from human FGFR4 (Phospho-Tyr754) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2663146 |
Phospho-FGFR4 (Tyr754) Polyclonal Antibody detects endogenous levels of FGFR4 only when phosphorylated at Tyr754.
FGFR4 (Fibroblast Growth Factor Receptor 4), is a member of the FGFR family of receptor tyrosine kinases. This family regulates a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR4 protein is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation, migration, and in the regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism, and phosphate homeostasis. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD334; CTLA-2-beta protein; FGF Receptor 4; FGFR-4; Fibroblast growth factor receptor 4; fibroblast growth factor receptor 4 16 minus form; hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; Protein-tyrosine kinase receptor MPK-11; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
基因别名: CD334; Fgfr-4; FGFR4; JTK2; Mpk-11; TKF
UniProt ID: (Human) P22455, (Rat) Q498D6, (Mouse) Q03142
Entrez Gene ID: (Human) 2264, (Rat) 25114, (Mouse) 14186
分子生物学功能:
transmembrane signal receptor