Invitrogen

Phospho-GATA2 (Ser401) Polyclonal Antibody

查看其他7个GATA2抗体

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Phospho-GATA2 (Ser401) Antibody in Western Blot (WB) — Western blot analysis of extracts from JK cells (Lane 2) using GATA2 (pSer401) polyclonal antibody (Product # PA5-37583) compared to the same antibody preincubated with a blocking peptide (Lane 1).

产品细节

Applications

Tested Dilution

Publications

免疫印迹 (WB)

1:500-1:1,000

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of Serine 401(K-M-S(p)-N-K) derived from Human GATA2.

偶联物

Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

RRID

AB_2554191

产品详细信息

A suggested positive control for Western blot is JK cells.

靶标信息

GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; MGC2306

基因别名: DCML; Gata-2; GATA2; IMD21; MONOMAC; NFE1B

UniProt ID: (Human) P23769, (Mouse) O09100

Entrez Gene ID: (Human) 2624, (Mouse) 14461

分子生物学功能: DNA-binding transcription factor

negative regulation of transcription from RNA polymerase II promoter urogenital system development cell fate determination neuron migration embryonic placenta development transcription, DNA-templated transcription from RNA polymerase II promoter phagocytosis positive regulation of cytosolic calcium ion concentration heart development blood coagulation organ morphogenesis tissue development regulation of primitive erythrocyte differentiation ventral spinal cord interneuron differentiation cell differentiation in hindbrain commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron development pituitary gland development response to lipid somatic stem cell population maintenance regulation of histone acetylation eosinophil fate commitment inner ear morphogenesis mast cell degranulation negative regulation of fat cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of megakaryocyte differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter cell maturation digestive tract development homeostasis of number of cells within a tissue positive regulation of phagocytosis positive regulation of phagocytosis, engulfment definitive hemopoiesis semicircular canal development negative regulation of fat cell proliferation GABAergic neuron differentiation negative regulation of neural precursor cell proliferation regulation of forebrain neuron differentiation regulation of transcription, DNA-templated hemopoiesis cell differentiation neuron differentiation negative regulation of myeloid cell differentiation neuron fate commitment

参与通路

RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding zinc ion binding C2H2 zinc finger domain binding DNA binding sequence-specific DNA binding metal ion binding