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产品信息
PA5-37796
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence around phosphorylation site of Serine 417(L-E-M(p)-A-Q) derived from Human Girdin.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
RRID
AB_2554404
产品详细信息
A suggested positive control for IHC is human breast carcinoma.
靶标信息
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Akt phosphorylation enhancer; AKT-phosphorylation enhancer; APE; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; Girders of actin filament; girders of actin filaments; Girdin; GIV; HkRP1; Hook-related protein 1
基因别名: A430106J12Rik; AI848406; APE; C130096N06Rik; C330012F17Rik; CCDC88A; D130005J21Rik; GIRDIN; GIV; GRDN; HkRP1; KIAA1212
UniProt ID: (Human) Q3V6T2, (Mouse) Q5SNZ0
Entrez Gene ID: (Human) 55704, (Mouse) 108686
分子生物学功能:
membrane traffic protein
regulation of protein phosphorylation
DNA replication
regulation of DNA replication
regulation of neuron projection development
cell migration
lamellipodium assembly
TOR signaling
activation of protein kinase B activity
regulation of actin cytoskeleton organization
regulation of cell proliferation
membrane organization
nervous system development
