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Invitrogen
Phospho-GluR1 (Ser845) Polyclonal Antibody
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产品信息
PA1-12749
应用
建议稀释比
已发表文章
产品规格
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Sythetic peptide corresponding to amino acid residues surrounding phospho-Ser845 of rat GluR1
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
This antibody recognizes a ~100kD band corresponding to GluR1 phosphorylated at Ser845 in Western blots of rat brain extracts. Immunolabeling can blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide, and is completely eliminated by treatment with lambda-phosphatase.
靶标信息
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
