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Invitrogen
Phospho-JAK1 (Tyr1022, Tyr1023) Polyclonal Antibody
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产品信息
OPA1-03051A
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic JAK1 peptide that is phosphorylated at tyrosines 1022 and 1023.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
OPA1-03051A detects phospho-JAK1 (pTyr 1022/1023) in human and mouse samples. This product has been shown to not react with rat JAK1.
OPA1-03051A has been successfully used in Western blotting. By Western blot, this antibody detects an ~130 kDa protein representing JAK1 phosphorylated at tyrosines 1022 and 1023.
The OPA1-03051A immunogen is a synthetic peptide derived from a region of human JAK1 that contains tyrosines 1022 and 1023. This sequence is conserved in mouse and pig.
靶标信息
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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