应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:500-1:1,000 | - |
免疫组化(石蜡) (IHC (P)) |
1:50-1:100 | - |
产品规格 | |
---|---|
种属反应 |
Rat, Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyr931 (M-E-YP-L-P) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2556291 |
Janus Activating Kinase 2 (JAK2) is a non-rececptor tyrosine kinase involved in various processes such as cell growth, development, differentiation, and histone modifications. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting this gene can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EC 2.7.10.2; JAK 2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; kinase Jak2; Tyrosine-protein kinase JAK2
基因别名: Fd17; JAK2; JTK10; THCYT3
UniProt ID: (Human) O60674, (Rat) Q62689, (Mouse) Q62120
Entrez Gene ID: (Human) 3717, (Rat) 24514, (Mouse) 16452