Invitrogen

Phospho-JDP2 (Thr148) Polyclonal Antibody

查看其他8个JDP2抗体

产品信息

PA5-64681

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-

产品规格
种属反应	Human, Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human JDP-2 (Phospho-Thr148) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2663107

产品详细信息

Phospho-JDP2 (Thr148) Polyclonal Antibody detects endogenous levels of JDP2 only when phosphorylated at Thr148.

靶标信息

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: c-Jun dimerization protein 2; Jun dimerization protein 2; progesterone receptor co-activator

基因别名: Jdp-2; JDP2; JUNDM2; Jundp2; TIF

UniProt ID: (Human) Q8WYK2, (Mouse) P97875, (Rat) Q78E65

Entrez Gene ID: (Human) 122953, (Mouse) 81703, (Rat) 116674

分子生物学功能: basic leucine zipper transcription factor

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated positive regulation of histone deacetylation negative regulation of fat cell differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of histone deacetylation

参与通路

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein binding protein heterodimerization activity DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding