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Invitrogen
Phospho-MEK3/MEK6 (Ser189, Ser207) Polyclonal Antibody
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 2
Phospho-MEK3/MEK6 (Ser189, Ser207) Antibody (PA5-17887) in WB
Western blot was performed using Anti-Phospho-MEK3/MEK6 (Ser189, Ser207) Polyclonal Antibody(Product # PA5-17887) and a 39 kDa and 37 kDa bands corresponding to Phospho-MEK3/MEK6 (Ser189, Ser207) were observed in A549 cell line treated with Anisomycin and not treated with PMA. Whole Cell Extract-WCL (30 µg lysate) of A549 (Lane 1), A549 treated with 25 µg/ml Anisomycin for 30 minutes (Lane 2) and A549 treat... View More
Product Details
PA5-17887
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues around pSer189/207 of human MKK3
Conjugate
Unconjugated
形式
Liquid
浓度
40 µg/mL
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
RRID
AB_10980081
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 3; MAP kinase kinase 6; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MEK 3; MEK 6; mitogen activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; OTTHUMP00000166044; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; SAPKK3; Stress-activated protein kinase kinase 2; Stress-activated protein kinase kinase 3
Gene Aliases: AW212142; MAP2K3; MAP2K6; MAPKK3; MAPKK6; MEK3; MEK6; MKK3; MKK6; mMKK3b; PRKMK3; PRKMK6; SAPKK-2; SAPKK-3; SAPKK2; SAPKK3; SKK2; SKK3
UniProt ID: (Human) P46734, (Human) P52564, (Mouse) O09110, (Mouse) P70236
Entrez Gene ID: (Human) 5606, (Human) 5608, (Mouse) 26397, (Rat) 303200, (Mouse) 26399, (Rat) 114495
Molecular Function:
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPK activity
inflammatory response
signal transduction
peptidyl-tyrosine phosphorylation
proteolysis in other organism
regulation of cytokine biosynthetic process
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
cardiac muscle contraction
response to ischemia
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
DNA damage induced protein phosphorylation
cell cycle arrest
ovulation cycle process
positive regulation of prostaglandin secretion
response to drug
positive regulation of apoptotic process
positive regulation of nitric-oxide synthase biosynthetic process
nucleotide-binding oligomerization domain containing signaling pathway
cellular response to sorbitol
protein phosphorylation
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
positive regulation of protein phosphorylation
heart development
cellular response to lipopolysaccharide
regulation of signal transduction
intracellular signal transduction
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
protein kinase binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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