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Invitrogen
Phospho-MEK3/MEK6 (Ser189, Thr193, Ser207, Thr211) Polyclonal Antibody
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Phospho-MEK3/MEK6 (Ser189, Thr193, Ser207, Thr211) Antibody (44470G) in WB
Mal-E-tagged fusion protein expressing MEK6 left inactivated (6) or activated with MEKK (1-5) was spiked into background extracts and resolved by SDS-PAGE on a 10% Tris-glycine gel and transferred to PVDF. The membrane was blocked with a 5% BSA-TBST buffer overnight at 4oC, then incubated with the MEK3/6 (pSpT189/193)/ (pSpT207/211) antibody for two hours at room temperature in a 3% BSA-TBST buffer, followi... View More
产品信息
44470G
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human MEK3 that contains serine 189 and threonine 193.
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2533659
靶标信息
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 3; MAP kinase kinase 6; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MEK 3; MEK 6; OTTHUMP00000166044; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; Stress-activated protein kinase kinase 2; Stress-activated protein kinase kinase 3
基因别名: MAP2K3; MAP2K6; MAPKK3; MAPKK6; MEK3; MEK6; MKK3; MKK6; PRKMK3; PRKMK6; SAPKK-2; SAPKK-3; SAPKK2; SAPKK3; SKK2; SKK3
UniProt ID: (Human) P46734, (Human) P52564
Entrez Gene ID: (Human) 5606, (Human) 5608
MAPK cascade
activation of MAPK activity
inflammatory response
signal transduction
peptidyl-tyrosine phosphorylation
proteolysis in other organism
regulation of cytokine biosynthetic process
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
cardiac muscle contraction
response to ischemia
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
DNA damage induced protein phosphorylation
cell cycle arrest
ovulation cycle process
positive regulation of prostaglandin secretion
response to drug
positive regulation of apoptotic process
positive regulation of nitric-oxide synthase biosynthetic process
nucleotide-binding oligomerization domain containing signaling pathway
cellular response to sorbitol
