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产品信息
44-478
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:1,000 | 查看1篇已发表文章 1篇已发表文章 |
| 产品规格 | |
|---|---|
种属反应 |
Human |
已发表种属 |
Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human MEK7 that contains serine 271 and threonine 275. |
偶联物 |
Unconjugated |
形式 |
Liquid |
纯化类型 |
Antigen affinity chromatography |
保存液 |
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2533660 |
靶标信息
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; MAP kinase kinase 7; MAP2K4; MAPK/ERK kinase 7; MAPKK 4; MEK 7; SAPK kinase 4; SAPKK-1; SAPKK1; Stress-activated protein kinase kinase 4
基因别名: JNKK2; MAP2K7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; SKK4
UniProt ID: (Human) O14733
Entrez Gene ID: (Human) 5609
apoptotic process
response to osmotic stress
signal transduction
JNK cascade
activation of JUN kinase activity
response to heat
response to UV
peptidyl-tyrosine phosphorylation
positive regulation of telomere maintenance via telomerase
response to tumor necrosis factor
proteolysis in other organism
Fc-epsilon receptor signaling pathway
positive regulation of neuron apoptotic process
stress-activated MAPK cascade
positive regulation of telomerase activity
cellular response to sorbitol
positive regulation of telomere capping
magnesium ion binding
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
protein C-terminus binding
JUN kinase kinase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
