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7TM Antibodies
Phospho-MRGPRX2 Mas-related Receptor (Ser327, Ser328) Polyclonal Antibody
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Phospho-MRGPRX2 Mas-related Receptor (Ser327, Ser328) Antibody (7TM0157B) in WB
Agonist-induced Serine327/Serine328 phosphorylation of the MRGPRX2 Mas-related Receptor. Upper panel, HEK293 cells stably expressing the MRGPRX2 Receptor (MRGPRX2) were either not exposed or exposed to 100 nM specific Agonist ZINC-3573 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS327/pS328-MRGPRX2 antibody (7TM0157B) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed... View More
产品信息
7TM0157B
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human MRGPRX2 around the phosphorylation site of Ser327/Ser328.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein-coupled receptor MRGX2; Mas-related G protein-coupled receptor G3; Mas-related G-protein coupled receptor member X2; MAS-related GPR, member X2
基因别名: MGRG3; MRGPRX2; MRGX2
UniProt ID: (Human) Q96LB1
Entrez Gene ID: (Human) 117194
