Invitrogen

Phospho-MYLK (Tyr464) Polyclonal Antibody

产品信息

PA5-64763

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-

产品规格
种属反应	Human
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human MLCK (Phospho-Tyr464) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2663368

产品详细信息

Phospho-MYLK (Tyr464) Polyclonal Antibody detects endogenous levels of MYLK only when phosphorylated at Tyr464.

靶标信息

MLCK, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Kinase-related protein; KRP; MLCK; Myosin light chain kinase, smooth muscle; Myosin light chain kinase, smooth muscle, deglutamylated form; myosin, light polypeptide kinase; smooth muscle myosin light chain kinase; Telokin

基因别名: AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK; MYLK1; smMLCK

UniProt ID: (Human) Q15746

Entrez Gene ID: (Human) 4638

功能

positive regulation of defense response to virus by host protein phosphorylation muscle contraction smooth muscle contraction tonic smooth muscle contraction positive regulation of cell migration bleb assembly positive regulation of calcium ion transport aorta smooth muscle tissue morphogenesis cellular hypotonic response positive regulation of wound healing mitophagy in response to mitochondrial depolarization xenophagy

参与通路

actin binding myosin light chain kinase activity protein binding calmodulin binding ATP binding metal ion binding

Phospho-MYLK (Tyr464) Polyclonal Antibody

产品信息

PA5-64763

免疫印迹 (WB)

种属反应

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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