Invitrogen

Phospho-NACA (Thr159) Polyclonal Antibody

产品信息

PA5-64694

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-

产品规格
种属反应	Human, Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	A synthesized peptide derived from human NACA (Phospho-Thr159) 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2663603

产品详细信息

Phospho-NACA (Thr159) Polyclonal Antibody detects endogenous levels of NACA only when phosphorylated at Thr159.

靶标信息

NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Alpha-NAC; Alpha-NAC, muscle-specific form; Alpha-NAC/1.9.2; Hom s 2; NAC-alpha; nascent polypeptide-associated complex alpha subunit; Nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; skNAC

基因别名: AL022831; AL024382; Gm1878; HSD48; mKIAA0363; NAC-alpha; NACA; NACA1; skNAC

UniProt ID: (Human) Q13765, (Mouse) Q60817

Entrez Gene ID: (Human) 4666, (Rat) 288770, (Mouse) 17938

分子生物学功能: basic helix-loop-helix transcription factor