Invitrogen

Phospho-NeuroD1 (Ser274) Polyclonal Antibody

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Phospho-NeuroD1 (Ser274) Antibody in Western Blot (WB) — Western blot analysis of extracts from Hela cells treated with UV using Neuro D (pSer274) polyclonal antibody (Product # PA5-37657) (left) or the same antibody preincubated with a blocking peptide (right).

产品信息

PA5-37657

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:1,000	-

产品规格
种属反应	Human, Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Peptide sequence around phosphorylation site of Serine 274(P-L-S(p)-P-P) derived from Human Neuro D.
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2554265

产品详细信息

A suggested positive control for Western blot is HeLa cells.

靶标信息

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Basic helix-loop-helix factor 1; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; Beta-cell E-box transcriptional activator 2; Beta2; BHF-1; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; NeuroD1; neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD

基因别名: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1

UniProt ID: (Human) Q13562, (Rat) Q64289, (Mouse) Q60867

Entrez Gene ID: (Human) 4760, (Rat) 29458, (Mouse) 18012

分子生物学功能: basic helix-loop-helix transcription factor

pancreatic A cell fate commitment pancreatic PP cell fate commitment transcription from RNA polymerase II promoter nucleocytoplasmic transport nitric oxide mediated signal transduction response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion endocrine pancreas development amacrine cell differentiation enteroendocrine cell differentiation response to drug glucose homeostasis positive regulation of apoptotic process positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade embryonic organ morphogenesis neuron development inner ear development regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity regulation of intestinal epithelial structure maintenance regulation of cell cycle arrest cellular response to glucose stimulus negative regulation of type B pancreatic cell apoptotic process positive regulation of transcription regulatory region DNA binding transcription, DNA-templated hindbrain development camera-type eye development cell fate commitment regulation of neuron differentiation regulation of transcription, DNA-templated multicellular organism development nervous system development cell differentiation

参与通路

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding sequence-specific DNA binding protein heterodimerization activity E-box binding DNA binding double-stranded DNA binding protein dimerization activity