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Invitrogen
Phospho-PAK1/2/3 (Ser141) Polyclonal Antibody
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产品信息
PA1-26711
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to a region of human PAK2 that contains serine 141. This sequence is conserved in rat and rabbit.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-26711 detects PAK1 + PAK2 + PAK3 (phospho S141) from human samples. PA1-26711 is expected to cross react with rabbit and rat due to sequence homology.
PA1-26711 has been successfully used in Western blot procedures.
The PA1-26711 immunogen is a synthetic phosphopeptide corresponding to a region of human PAK2 that contains serine 141. This sequence is conserved in rat and rabbit.
靶标信息
In mammals, there are several identified isoforms of p21-Activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated wit X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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