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Invitrogen
Phospho-PAK2 (Ser141) Polyclonal Antibody
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Phospho-PAK2 (Ser141) Antibody (PA5-39750) in WB
Western blot analysis of Phospho-PAK2 pSer141 in extracts from HepG2 cells treated with Adriamycin (0.5µM, 24hours) and Jurkat cells treated with PMA (125 ng/mL, 30 mins) using a Phospho-PAK2 pSer141 polyclonal antibody (Product # PA5-39750).
产品信息
PA5-39750
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human PAK2 around the phosphorylation site of Ser141 (Y-L-SP-F-T)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
靶标信息
PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, or proliferation. It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformation change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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