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产品信息
PA5-17636
产品规格
种属反应
Guinea pig,
Human,
Mouse,
Pig
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding pSer474 of human PAK4
偶联物
Unconjugated
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
RRID
AB_10984818
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with phosphorylated PAK1, PAK2 or PAK3.
靶标信息
PAK4 is highly expressed in prostate, testis and colon. PAK4 interacts tightly with GTP-bound but not GDP-bound CDC42 and weakly with RAC. PAK4 phosphorylates and autophosphorylates and also activates the JNK pathway. PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 4; p21(CDKN1A)-activated kinase 6; p21(CDKN1A)-activated kinase 7; p21-activated kinase 4; p21-activated kinase 5; p21-activated kinase 6; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK-4; PAK-5; PAK-6; PAK-7; protein kinase PAK5; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4; Serine/threonine-protein kinase PAK 5; Serine/threonine-protein kinase PAK 6; serine/threonine-protein kinase PAK 6-like; serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7
基因别名: 2900083L08Rik; 4732456M09; 5730488L07Rik; 6430627N20; AW555722; KIAA1142; KIAA1264; mKIAA1142; PAK4; PAK5; PAK6; PAK7
UniProt ID: (Human) O96013, (Human) Q9P286, (Human) Q9NQU5, (Mouse) Q8BTW9, (Mouse) Q3ULB5, (Mouse) Q8C015
Entrez Gene ID: (Pig) 100627936, (Human) 10298, (Pig) 100152316, (Human) 57144, (Human) 56924, (Pig) 100153981, (Mouse) 70584, (Guinea pig) 100736193, (Guinea pig) 100731594, (Mouse) 214230, (Guinea pig) 100713585, (Mouse) 241656
mitotic cell cycle
apoptotic process
movement of cell or subcellular component
cytoskeleton organization
signal transduction
cell proliferation
cell growth
cell migration
signal transduction by protein phosphorylation
dendritic spine development
cellular response to organic cyclic compound
cell-cell adhesion
learning
memory
locomotory behavior
negative regulation of extrinsic apoptotic signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
Rho protein signal transduction
regulation of mitotic cell cycle
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
regulation of MAPK cascade
phosphorylation
protein kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
cadherin binding involved in cell-cell adhesion
protein serine/threonine kinase activity
Rac GTPase binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
