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Invitrogen
Phospho-PDGFRA/PDGFRB (Tyr572, Tyr574) Polyclonal Antibody
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产品信息
PA1-28435
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho peptide, containing Tyrosine 572 and 574 of Human PDGFR alpha. This corresponds to Tyrosine 579 and 581 of Human PDGFR beta. The sequence is conserved in PDGFR alpha mouse, rat and frog.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-28435 detects PDGFR alpha + beta from mouse, human samples.
PA1-28435 has been successfully used in Western blot applications.
The PA1-28435 immunogen is: Synthetic phospho peptide, containing Tyrosine 572 and 574 of Human PDGFR alpha. This corresponds to Tyrosine 579 and 581 of Human PDGFR beta. The sequence is conserved in PDGFR alpha mouse, rat and frog.
靶标信息
PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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