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Invitrogen
Phospho-PDGFRB (Tyr1021) Recombinant Superclonal Antibody (6HCLC)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Phospho-PDGFRB (Tyr1021) Antibody (711359) in ICC/IF
For immunofluorescence analysis, NIH 3T3 cells were fixed and permeabilized for detection of endogenous PDGFR beta (pY 1021) using Anti- PDGFR beta (pY 1021) Recombinant Rabbit Polyclonal Antibody (Product # 711359, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) were stained using SlowFade® Gol... View More
产品信息
711359
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
6HCLC
抗原
Peptide corresponding to Human PDGFRB (aa 1016-1024)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2632975
产品详细信息
This antibody is predicted to react with Monkey, Bovine and Sheep
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; platelet-derived growth factor receptor, beta polypeptide
基因别名: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT
UniProt ID: (Human) P09619, (Mouse) P05622
Entrez Gene ID: (Human) 5159, (Mouse) 18596
protein tyrosine kinase activity
platelet activating factor receptor activity
platelet-derived growth factor-activated receptor activity
platelet-derived growth factor beta-receptor activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
platelet-derived growth factor receptor binding
protein binding
ATP binding
protein kinase binding
vascular endothelial growth factor binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
platelet-derived growth factor binding
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
signal transducer activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
MAPK cascade
glycosaminoglycan biosynthetic process
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
response to toxic substance
positive regulation of phospholipase C activity
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
response to estradiol
positive regulation of phosphoprotein phosphatase activity
response to retinoic acid
regulation of actin cytoskeleton organization
positive regulation of collagen biosynthetic process
response to fluid shear stress
cell migration involved in vasculogenesis
metanephric mesenchymal cell migration
platelet-derived growth factor receptor-beta signaling pathway
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
aorta morphogenesis
cellular response to platelet-derived growth factor stimulus
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
wound healing
response to hydrogen peroxide
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of mitotic nuclear division
phosphatidylinositol metabolic process
protein autophosphorylation
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
inner ear development
positive regulation of chemotaxis
cardiac myofibril assembly
response to hyperoxia
cell chemotaxis
cell migration involved in coronary angiogenesis
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
smooth muscle cell chemotaxis
metanephric mesenchyme development
metanephric glomerular mesangial cell proliferation involved in metanephros development
metanephric glomerular capillary formation
metanephric comma-shaped body morphogenesis
metanephric S-shaped body morphogenesis
positive regulation of calcium ion import
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
in utero embryonic development
kidney development
tissue homeostasis
protein phosphorylation
nitrogen compound metabolic process
chemotaxis
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
phosphorylation
hemopoiesis
adrenal gland development
intracellular signal transduction
skeletal system morphogenesis
smooth muscle tissue development
regulation of peptidyl-tyrosine phosphorylation
cardiac vascular smooth muscle cell differentiation
