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Invitrogen
Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody
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Phospho-PI3K p85/p55 (Tyr458, Tyr199) Antibody (PA5-99367) in ICC/IF
Immunofluorescent analysis of Phospho-PI3K p85/p55 (Tyr458, Tyr199) in NIH/3T3 cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% saponin, blocked with 10% serum (45 min, 37°C) incubated with Phospho-PI3K p85/p55 (Tyr458, Tyr199) polyclonal antibody (Product # PA5-99367) using a dilution of 1:400 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) at a dilution of ... View More
产品信息
PA5-99367
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PI3-kinase p85 alpha/ gamma around the phosphorylation site of Tyr467/199.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
靶标信息
Phosphoinositide 3-kinase (PI3K, phospho PI3K) Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it also binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
