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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PKC alpha Antibodies

          Invitrogen

          Phospho-PKC alpha (Thr638) Polyclonal Antibody

          View all (37) PKC alpha antibodies
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          Cite Phospho-PKC alpha (Thr638) Polyclonal Antibody

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          Product Details

          PA5-17904

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          1:1,000
          -

          免疫沉淀 (IP)

          1:100
          -
          产品规格

          Species Reactivity

          Hamster, Human, Mouse, Non-human primate, Rat

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          Synthetic phosphopeptide corresponding to residues surrounding pThr638 of human PKC alpha
          View immunogen

          Conjugate

          Unconjugated

          形式

          Liquid

          纯化类型

          Antigen affinity chromatography

          保存液

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          内含物

          no preservative

          保存条件

          -20°C

          RRID

          AB_10989347

          Product Specific Information

          It is not recommended to aliquot this antibody.

          Target Information

          The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          Cite this product

          Bioinformatics

          Protein Aliases: aging-associated gene 6; EC 2.7.11.13; FHC; FTH; FTHL6; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; PKC-A; PKC-alpha; PKC-III; PLIF; Protein kinase C alpha type; protein kinase C, alpha; protein kinase c-alpha

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          Gene Aliases: AAG6; AI875142; PKC-alpha; PKCA; PRKACA; PRKCA

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          UniProt ID: (Human) P17252, (Mouse) P20444

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          Entrez Gene ID: (Human) 5578, (Mouse) 18750, (Rat) 24680

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          Molecular Function: non-receptor serine/threonine protein kinase

          Function(s)
          angiogenesis positive regulation of endothelial cell proliferation desmosome assembly protein phosphorylation mitotic nuclear envelope disassembly cell adhesion activation of adenylate cyclase activity negative regulation of adenylate cyclase activity positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy peptidyl-serine phosphorylation platelet activation positive regulation of cell migration positive regulation of lipopolysaccharide-mediated signaling pathway negative regulation of glial cell apoptotic process histone H3-T6 phosphorylation intracellular signal transduction regulation of mRNA stability positive regulation of blood vessel endothelial cell migration positive regulation of macrophage differentiation positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of mitotic cell cycle regulation of insulin secretion positive regulation of ERK1 and ERK2 cascade response to interleukin-1 regulation of platelet aggregation apoptotic signaling pathway positive regulation of dense core granule biogenesis inactivation of MAPK activity response to reactive oxygen species negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of the force of heart contraction chondrocyte differentiation negative regulation of protein kinase activity cellular calcium ion homeostasis apoptotic process regulation of muscle contraction learning or memory negative regulation of cell proliferation phosphorylation negative regulation of translation peptidyl-threonine phosphorylation central nervous system neuron axonogenesis neutrophil chemotaxis response to estradiol peptidyl-serine autophosphorylation response to ethanol negative regulation of heart contraction positive regulation of exocytosis negative regulation of glucose import negative regulation of insulin receptor signaling pathway protein autophosphorylation regulation of receptor-mediated endocytosis positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation induction of positive chemotaxis positive regulation of synapse assembly cellular response to carbohydrate stimulus intrinsic apoptotic signaling pathway aging response to mechanical stimulus response to toxic substance response to organic cyclic compound response to peptide hormone establishment of protein localization response to antibiotic response to corticosterone
          Process(es)
          protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein binding ATP binding zinc ion binding enzyme binding histone kinase activity (H3-T6 specific) nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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