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Product Details
PA5-17904
产品规格
Species Reactivity
Hamster,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pThr638 of human PKC alpha
Conjugate
Unconjugated
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
RRID
AB_10989347
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: aging-associated gene 6; EC 2.7.11.13; FHC; FTH; FTHL6; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; PKC-A; PKC-alpha; PKC-III; PLIF; Protein kinase C alpha type; protein kinase C, alpha; protein kinase c-alpha
Gene Aliases: AAG6; AI875142; PKC-alpha; PKCA; PRKACA; PRKCA
UniProt ID: (Human) P17252, (Mouse) P20444
Entrez Gene ID: (Human) 5578, (Mouse) 18750, (Rat) 24680
Molecular Function:
non-receptor serine/threonine protein kinase
angiogenesis
positive regulation of endothelial cell proliferation
desmosome assembly
protein phosphorylation
mitotic nuclear envelope disassembly
cell adhesion
activation of adenylate cyclase activity
negative regulation of adenylate cyclase activity
positive regulation of endothelial cell migration
positive regulation of cardiac muscle hypertrophy
peptidyl-serine phosphorylation
platelet activation
positive regulation of cell migration
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of glial cell apoptotic process
histone H3-T6 phosphorylation
intracellular signal transduction
regulation of mRNA stability
positive regulation of blood vessel endothelial cell migration
positive regulation of macrophage differentiation
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of mitotic cell cycle
regulation of insulin secretion
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
regulation of platelet aggregation
apoptotic signaling pathway
positive regulation of dense core granule biogenesis
inactivation of MAPK activity
response to reactive oxygen species
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
regulation of the force of heart contraction
chondrocyte differentiation
negative regulation of protein kinase activity
cellular calcium ion homeostasis
apoptotic process
regulation of muscle contraction
learning or memory
negative regulation of cell proliferation
phosphorylation
negative regulation of translation
peptidyl-threonine phosphorylation
central nervous system neuron axonogenesis
neutrophil chemotaxis
response to estradiol
peptidyl-serine autophosphorylation
response to ethanol
negative regulation of heart contraction
positive regulation of exocytosis
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
protein autophosphorylation
regulation of receptor-mediated endocytosis
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
regulation of peptidyl-tyrosine phosphorylation
induction of positive chemotaxis
positive regulation of synapse assembly
cellular response to carbohydrate stimulus
intrinsic apoptotic signaling pathway
aging
response to mechanical stimulus
response to toxic substance
response to organic cyclic compound
response to peptide hormone
establishment of protein localization
response to antibiotic
response to corticosterone
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein binding
ATP binding
zinc ion binding
enzyme binding
histone kinase activity (H3-T6 specific)
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
Performance Guarantee
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