Invitrogen

Phospho-PKC alpha (Thr638) Polyclonal Antibody

查看其他36个PKC alpha抗体

产品细节

Applications

Tested Dilution

Publications

免疫印迹 (WB)

1:1,000

-

免疫沉淀 (IP)

1:100

-

产品规格

种属反应

Hamster, Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phosphopeptide corresponding to residues surrounding pThr638 of human PKC alpha

偶联物

Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

RRID

AB_10989347

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: aging-associated gene 6; EC 2.7.11.13; FHC; FTH; FTHL6; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; PKC-A; PKC-alpha; PKC-III; PLIF; Protein kinase C alpha type; protein kinase C, alpha; protein kinase c-alpha

基因别名: AAG6; AI875142; PKC-alpha; PKCA; PRKACA; PRKCA

UniProt ID: (Human) P17252, (Mouse) P20444

Entrez Gene ID: (Human) 5578, (Mouse) 18750, (Rat) 24680

分子生物学功能: non-receptor serine/threonine protein kinase

angiogenesis positive regulation of endothelial cell proliferation desmosome assembly protein phosphorylation mitotic nuclear envelope disassembly cell adhesion activation of adenylate cyclase activity negative regulation of adenylate cyclase activity positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy peptidyl-serine phosphorylation platelet activation positive regulation of cell migration positive regulation of lipopolysaccharide-mediated signaling pathway negative regulation of glial cell apoptotic process histone H3-T6 phosphorylation intracellular signal transduction regulation of mRNA stability positive regulation of blood vessel endothelial cell migration positive regulation of macrophage differentiation positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of mitotic cell cycle regulation of insulin secretion positive regulation of ERK1 and ERK2 cascade response to interleukin-1 regulation of platelet aggregation apoptotic signaling pathway positive regulation of dense core granule biogenesis inactivation of MAPK activity response to reactive oxygen species negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of the force of heart contraction chondrocyte differentiation negative regulation of protein kinase activity cellular calcium ion homeostasis apoptotic process regulation of muscle contraction learning or memory negative regulation of cell proliferation phosphorylation negative regulation of translation peptidyl-threonine phosphorylation central nervous system neuron axonogenesis neutrophil chemotaxis response to estradiol peptidyl-serine autophosphorylation response to ethanol negative regulation of heart contraction positive regulation of exocytosis negative regulation of glucose import negative regulation of insulin receptor signaling pathway protein autophosphorylation regulation of receptor-mediated endocytosis positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation induction of positive chemotaxis positive regulation of synapse assembly cellular response to carbohydrate stimulus intrinsic apoptotic signaling pathway aging response to mechanical stimulus response to toxic substance response to organic cyclic compound response to peptide hormone establishment of protein localization response to antibiotic response to corticosterone

参与通路

protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein binding ATP binding zinc ion binding enzyme binding histone kinase activity (H3-T6 specific) nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding