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Product Details
PA5-17622
产品规格
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pThr514 of human PKCgamma
Conjugate
Unconjugated
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
RRID
AB_10985161
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: PKC-gamma; Protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma
Gene Aliases: PKC; PKC-gamma; PKCC; PKCG; PKCgamma; PKCI; Prkc; Prkcc; PRKCG; RATPKCI; SCA14
UniProt ID: (Human) P05129, (Mouse) P63318, (Rat) P63319
Entrez Gene ID: (Human) 5582, (Mouse) 18752, (Rat) 24681
Molecular Function:
non-receptor serine/threonine protein kinase
protein phosphorylation
chemical synaptic transmission
learning or memory
chemosensory behavior
phosphorylation
peptidyl-serine phosphorylation
platelet activation
negative regulation of protein ubiquitination
regulation of response to food
positive regulation of mismatch repair
intracellular signal transduction
negative regulation of protein catabolic process
regulation of circadian rhythm
response to morphine
negative regulation of neuron apoptotic process
protein autophosphorylation
response to pain
rhythmic process
regulation of phagocytosis
innervation
negative regulation of proteasomal protein catabolic process
protein kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein serine/threonine/tyrosine kinase activity
ATP binding
zinc ion binding
nucleotide binding
protein serine/threonine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
Performance Guarantee
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