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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PKC gamma Antibodies

          Invitrogen

          Phospho-PKC gamma (Thr514) Polyclonal Antibody

          View all (16) PKC gamma antibodies
          Datasheet
          Protocols
          Tech Support

          Cite Phospho-PKC gamma (Thr514) Polyclonal Antibody

          Datasheet
          Protocols
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          Product Details

          PA5-17622

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          1:1,000
          -

          免疫沉淀 (IP)

          1:100
          -
          产品规格

          Species Reactivity

          Human, Mouse, Non-human primate, Rat

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          Synthetic phosphopeptide corresponding to residues surrounding pThr514 of human PKCgamma
          View immunogen

          Conjugate

          Unconjugated

          形式

          Liquid

          纯化类型

          Antigen affinity chromatography

          保存液

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          内含物

          no preservative

          保存条件

          -20°C

          RRID

          AB_10985161

          Product Specific Information

          It is not recommended to aliquot this antibody.

          Target Information

          The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: PKC-gamma; Protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma

          View more View less

          Gene Aliases: PKC; PKC-gamma; PKCC; PKCG; PKCgamma; PKCI; Prkc; Prkcc; PRKCG; RATPKCI; SCA14

          View more View less

          UniProt ID: (Human) P05129, (Mouse) P63318, (Rat) P63319

          View more View less

          Entrez Gene ID: (Human) 5582, (Mouse) 18752, (Rat) 24681

          View more View less

          Molecular Function: non-receptor serine/threonine protein kinase

          Function(s)
          protein phosphorylation chemical synaptic transmission learning or memory chemosensory behavior phosphorylation peptidyl-serine phosphorylation platelet activation negative regulation of protein ubiquitination regulation of response to food positive regulation of mismatch repair intracellular signal transduction negative regulation of protein catabolic process regulation of circadian rhythm response to morphine negative regulation of neuron apoptotic process protein autophosphorylation response to pain rhythmic process regulation of phagocytosis innervation negative regulation of proteasomal protein catabolic process
          Process(es)
          protein kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein serine/threonine/tyrosine kinase activity ATP binding zinc ion binding nucleotide binding protein serine/threonine kinase activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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