Invitrogen

Phospho-PKC gamma (Thr514) Polyclonal Antibody

产品信息

PA5-17622

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-
免疫沉淀 (IP)	1:100	-

产品规格
种属反应	Human, Mouse, Non-human primate, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic phosphopeptide corresponding to residues surrounding pThr514 of human PKCgamma
偶联物	Unconjugated
形式	Liquid
纯化类型	Antigen affinity chromatography
保存液	0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物	no preservative
保存条件	-20°C
RRID	AB_10985161

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

仅用于科研。不用于诊断过程。未经明确授权不得转售。